Estimate overall risk and vaccine efficacy — est_overall • vaccine

Estimate overall risk and vaccine efficacy.

Usage

est_overall(dat, t_0, method = "Cox", risk = TRUE, ve = TRUE)

Arguments

dat: A data object returned by load_data
t_0: Time point of interest
method: One of c("KM", "Cox"), corresponding to either a Kaplan-Meier estimator ("KM") or a marginalized Cox proportional hazards model ("Cox").
risk: Boolean. If TRUE, the controlled risk (CR) curve is computed.
ve: Boolean. If TRUE, the controlled vaccine efficacy (CVE) curve is computed.

Value

A dataframe containing estimates

Examples

data(hvtn505)
dat <- load_data(time="HIVwk28preunblfu", event="HIVwk28preunbl", vacc="trt",
                 marker="IgG_V2", covariates=c("age","BMI","bhvrisk"),
                 weights="wt", ph2="casecontrol", data=hvtn505)
est_overall(dat=dat, t_0=578, method="KM")